Therapeutic monoclonal antibodies: from bench to clinic

Foreword

Preface

Contributors

Part I. Antibody Basics

1. Therapeutic Monoclonal Antibodies: Past, Present, and Future / William R. Strohl

2. Antibody Molecular Structure / Robyn L Stanfield / Ian A, Wilson

3. Glycosylation of Therapeutic IgGs / Yusuke Mimura / Roy Jefferis / Yuka Mimura-Kimura / Jodie Abrahams / Pauline M. Rudd

4. Antibody Databases and Tools: The IMGT® Experience / Marie-Paule Lefranc

Part II. Antibody Sources

5. Human Antibodies from Transgenic Mice / Nils Lanberg

6. Rabbit Hybridoma / Weimin Zhu / Guo-Liang Yu

7. Human Antibody Repertoire Libraries / David Lowe / Tristan J. Vaughan

Part III. In Vitro Display Technology

8. Antibody Phage Display / Michael Must / Holger Thie / Thomas Schirrmann / Stefan Dübel

9. Yeast Surface Display / Jennifer L Lahti / Jennifer R. Cochran

10. Ribosomal Display / George Thorn

11. Bacterial Display of Antibodies / Thomas J. Van Blarcom / Barrett R. Harvey

12. Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells / Ernest S. Smith / Maurice Zauderer

Part IV. Antibody Engineering

13. Antibody Engineering: Humanization, Affinity Maturation, and Selection Techniques / Juan C. Almagro / William R. Strohl

14. Modulation of Serum Protein Homeostasis and Transcytosis by the Neonatal Fc Receptor / William F. Dall'Acqva / Herren Wu

15. Engineering the Antibody Fc Region for Optimal Effector Function / Greg A. Lazar / John R. Desjarlais

Part V. Physiology And In Vivo Biology

16. Antibody-Complement Interaction / Kileen L Mershon / Skene L Morrison

17. Bacteria Immunoglobulin-Binding Proteins: Biology and Practical Applications / Leslie Cope / Tessie McNeely

18. Immunogenicity Screening Using in Silico Methods; Correlation between T-Cell Epitope Content and Clinical Immunogenicity of Monoclonal Antibodies / Si-Han Hat / Julie A. McMurry / Paul M. Knopf / William Martin / Anne S. De Groot

19. Monoclonal Antibody Pharmacokinetics and Pharmacodynamics / Christopher R. Gibson / Punam Sandhu / William D. Hanley

20. Biodistribution and Imaging / Tove Olafsen / Anna M. Wu

21. Antibodies and the Blood-Brain Barrier / Angela R- Jones / Eric V Shusta

Part VI. Antibody Characterization

22. Determination of Equilibrium Dissociation Constants / Robin E. Ernst / Katrina N. High / Tom R. Glass / Qinjian Zhao

23. Molecular and Functional Characterization of Monoclonal Antibodies / Qinjian Zhao / Terrance A. Stadheim / Lorenzo Chen / Michael W. Washabaugh

24. Characterization of Heterogeneity in Monoclonal Antibody Products / Yang Wang / Michael W. Washabaugh / Qinjian Zhao

Part VII. Antibody Expression

25. Antibody Expression in Mammalian Cells / Fubao Wang / Lorenzo Chen / Neal Connors / Henryk Mach

26. Production of Antibodies in Pichia pastoris / Juergen H. Nett

27. Production of Antibody Fab' Fragments in E. coli / David P. Humphreys / Leigh Bowering

28. Production of Human Therapeutic Monoclonal Antibodies in Chicken Eggs / Lei Zhu / Robert J. Etches

29. Production of Antibodies in Plants / Kevin M. Cox / Jeffrey T. Regan / Jason D. Sterling / Vincent P. M. Wingate / Lynn F. Dickey

Part VIII. Therapeutic Antibodies

30. The Formulation and Delivery of Monoclonal Antibodies / Vikas K. Sharma / Hung-Wei Chih / Randall J. Mrsny / Ann L. Dougherty

31. Therapeutic Antibodies in Clinical Use and Leading Clinical Candidates / Ningyan Zhang / Brent R. Williams / Ping Lu / Zhiqiang An / Chen-Ni Chin

32. Follow-On Protein Products: What, Where, When, How? / Brent R. Williams / William R. Strohl

33. Monomeric Fc Fusion Molecules / Jennifer A. Dumont / Susan C. Low / Robert T. Peters / Alan J. Bitonti

34. Radioimmunotherapy: Current Status and Future Directions / Neeta Pandit-Taskar / Chaitanya R. Divgi

35. Antibody-Drug Conjugate Therapy / Stephen C. Alley / Dennis Benjamin / Che-Leung Law

Abbreviations

Index